Ellen DeGeneres and Kathy Griffin and her mom add to evening's laughs
Credit: Eric Liebowitz/ABC/AP

It was deja vu all over again as Ugly Betty and Brothers & Sisters once more took top honors at Saturday’s 19th Annual GLAAD Media Awards, at Hollywood’s Kodak Theatre.

Kathy Griffin, whose My Life on the D-List was named outstanding reality show, opened the ceremony with a little help from her mom, Maggie Griffin, who joined her daughter on-stage – and drew big laughs.

“Mom, who’s the gayest-looking person in the room tonight?” Griffin asked.

“Is Ryan Seacrest here?” Maggie inquired, deadpan.

For the second year in a row, the Gay & Lesbian Alliance Against Defamation selected ABC’s Ugly Betty and Brothers and Sisters as its outstanding series: Betty for comedy, and the other for drama.

“We’re not going to rest until we turn [all of the show’s characters] gay!” joked Brothers & Sisters executive producer Jon Robin Baitz. (The show currently features two gay characters.)

Jokes by Ellen DeGeneres

Janet Jackson won the Vanguard Award, while Sharon Stone presented Rufus Wainwright with the Stephen F. Kolzak award. Past Vanguard winners have included Liza Minnelli and Elizabeth Taylor – “both who have had their pictures taken with Michael Jackson,” observed presenter Ellen DeGeneres.

While Grey’s Anatomy didn’t make the GLAAD nominees list this year, one of its stars, T.R. Knight, turned out for the show, accompanied by partner Mark Cornelsen. Others attending included DeGeneres’s partner Portia de Rossi, as well as Sarah Silverman and Jimmy Kimmel.

The GLAAD Media Awards honor artists and programs committed to increasing awareness and understanding of the lesbian, gay, bisexual and transgender community. The awards are presented in four separate ceremonies in March, April and May in Los Angeles, New York, Miami and San Francisco.