'The Big Bang Theory' Cast, Then and Now

The beloved series, which has been on the air for more than a decade, ends on May 16

01 of 07

JOHNNY GALECKI

JOHNNY GALECKI
Robert Voets/CBS; Bill Inoshita/CBS

Stars as ... Leonard Hofstadter

His first episode aired in ... 2006

On life after The Big Bang Theory: "The only manner in which the cast has discussed wrapping [The Big Bang Theory] has been that we’re all going to be very sad when that day comes. But I think at this point everyone's very comfortable with 12 seasons being a good time to go home and see our families."

02 of 07

JIM PARSONS

JIM PARSONS
Robert Voets/CBS; Michael Yarish/CBS

Stars as ... Sheldon Cooper

His first episode aired in ... 2006

On his experience on The Big Bang Theory: "I feel very proud of the work we do. I love coming here, and one of the more astonishing things ... is how enjoyable it still is, to do this job, at a very visceral level as an actor, this far in."

03 of 07

KALEY CUOCO

KALEY CUOCO
Robert Voets/CBS; Sonja Flemming/CBS

Stars as ... Penny

Her first episode aired in ... 2007

On life after The Big Bang Theory: "I can’t really picture it. And I don’t think there really will be my life without it — I think it’ll always be there, I think it’ll always be running, I think we’ll always have those fans. It’s always going to be a part of me."

04 of 07

SIMON HELBERG

SIMON HELBERG
Michael Yarish/CBS (2)

Stars as ... Howard Wolowitz

His first episode aired in ... 2007

On his dream The Big Bang Theory guest star: "I always wanted Ringo [Starr] to come on ... I always thought he could be my dad!"

05 of 07

KUNAL NAYYAR

KUNAL NAYYAR
Sonja Flemming/CBS ; Michael Yarish/CBS

Stars as ... Raj Koothrappali

His first episode aired in ... 2007

On life after The Big Bang Theory: "I grew up on this show — I was a kid out of grad school. I don’t even know how to comprehend that."

06 of 07

MELISSA RAUCH

MELISSA RAUCH
Michael Yarish/CBS (2)

Stars as ... Bernadette Rostenkowski

Her first episode aired in ... 2009

On her The Big Bang Theory co-stars: "A lot of us hang out. It’s just a close-knit group. Kaley is the best at throwing parties. Mayim's the deep thinker, and Kunal is a big giggler. We all get along, and it's a nice family feel."

07 of 07

MAYIM BIALIK

MAYIM BIALIK
Sonja Flemming/CBS; Robert Voets/CBS

Stars as ... Amy Farrah Fowler

Her first episode aired in ... 2010

On how she's similar to her The Big Bang Theory character: "I was pretty studious, so I can relate to Amy a lot. I was actually a late bloomer to science and became interested when I was 15 while working on Blossom and had a tutor with a real passion for science."

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