“After 14 years together we have decided that ending our marriage is the best decision for our family,” Dane, 45, said in a statement to PEOPLE.
“We will continue our friendship and work as a team to co-parent our two beautiful girls as they are the most important thing in the world to us. We kindly ask that you respect our privacy during this time as we navigate the next phase of our lives.”
Gayheart, best known for films such as Jawbreaker and Scream 2, filed for divorce on Friday in Los Angeles according to court documents obtained by The Blast.
Gayheart cited irreconcilable differences as the reason for their split but did not say when they separated, instead the date of separation was listed as “TBD.”
The actress, 46, is requesting joint legal and physical custody of the couple’s two daughters: 7-year-old Billie and 6-year-old Georgia.
The Jawbreaker star is also seeking spousal support, according to the divorce documents.
Gayheart and the former Grey’s Anatomy star married in 2004 and have faced a number of challenges since then.
In 2009, an intimate video of Dane, Gayheart and another woman was released without their knowledge. Two years later, Dane entered into rehab for an addiction to painkillers following a sports injury.
Speaking to PEOPLE in 2014, the actor said, “We’ve all made mistakes. My one regret is that I got the person I love most wrapped up in all that: Rebecca.”
Of his family life, Dane said he feels happiest when he’s at home with them.
“I never had a family, and now I do,” he said, noting his father died when he was 7. “I know I’m a very lucky guy.”
Last year, he opened up about his battle with depression on the Today show where he spoke candidly about his struggles, which forced him to take a break from his TNT show The Last Ship.
“I took some time off — I was dealing with some depression, which was kind of odd to me,” he said. “I felt very conflicted about it because I didn’t really feel like I had anything to be depressed about.”
“Now I take a medication called Pristiq, which I thought just sounded like a good mood,” he added. “And the depression is gone.”
Dane rose to fame as Dr. Mark Sloan in ABC’s Grey’s Anatomy. His character was killed off in 2012 after six years on the show.