Ellen Pompeo on McDreamy's Death: 'His Loss Will Be Felt by All'

"I am honored and excited to tell the story of how Meredith goes on in the face of what feels like the impossible," Pompeo posted on Monday

The recently widowed Mrs. McDreamy is breaking her silence on her late TV husband’s untimely death.

Ellen Pompeo, 45, who plays Meredith Shepard on the hit medical drama, took to Twitter on Monday to address her on-screen husband, Patrick Dempsey‘s, shocking departure from the ABC series on Thursday’s episode.

“I have always said what keeps me going is the fans. Knowing we move you and inspire you,” Pompeo wrote in a post titled “Happy Monday.”

“There are so many people out there who have suffered tremendous loss and tragedy. Husbands and wives of soldiers, victims of senseless violence and parents who have lost children. People who get up each day and do what feels like is the impossible,” the actress continued.

“So it it for these people and in the spirit of resilience I am honored And excited to tell the story of how Meredith goes on in the face of what feels like the impossible. I hope you will all join me on her journey. With gratitude and respect, Ellen.”

Show creator/executive producer Shonda Rhimes also issued a statement on Dr. Derek Shepard’s fatal car wreck after the episode ran, saying, “Derek Shepherd is and will always be an incredibly important character – for Meredith, for me and for the fans. I absolutely never imagined saying goodbye to our ‘Mcdreamy.'”

She added, “His loss will be felt by all. Now, Meredith and the entire Grey’s Anatomy family are about to enter uncharted territory as we head into this new chapter of her life. The possibilities for what may come are endless. As Ellis Grey would say … the carousel never stops turning.”

Dempsey addressed his fans – and their thousands of mournful Tweets – on Friday, saying “I want to thank all the fans, what an incredible 11 yrs, I love you all.”

The season finale of Grey’s Anatomy airs May 14 on ABC.