Portia de Rossi underwent emergency surgery for appendicitis last month

Ellen DeGeneres recently drank multiple weed-infused beverages at what turned out to be the entirely wrong time.

Appearing on Jimmy Kimmel Live!'s 4/20 show on Tuesday, the talk show host recounted the night she drank three THC and CBD-infused drinks right before she learned that she needed to drive wife Portia de Rossi to the hospital for an appendectomy last month.

Noting that she's not typically a fan of marijuana, DeGeneres, 63, told host Jimmy Kimmel that she consumed "weed drinks" — Cann Social Tonics — which were recommended to her by Chelsea Handler.

Ellen DeGeneres on Portia’s Emergency Appendectomy
Credit: Jimmy Kimmel Live

"I drank one, and I didn't feel anything, so I drank three, and then I took two melatonin sleep pills. And I'm laying in bed, and I realize [Portia's] not in bed," she recalled. "She's moaning. I get out of bed, and she's on the ground on all fours, and I said, 'You're not OK.' She goes, 'I'm OK.' I said, 'No, unless you're playing Twister by yourself, you're not OK.' So I rushed her to the emergency room."

"You drove her yourself?" Kimmel, 53, asked DeGeneres, who replied, "I did. I mean, I kicked in, like my adrenaline, because I just had to rush her there. It's probably not safe, I shouldn't be saying any of this."

Ellen and Portia
Ellen DeGeneres and Portia de Rossi

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A source previously told PEOPLE that DeGeneres had rushed de Rossi, 48, to the hospital on March 19. "She was in a lot of pain," the source said at the time. "It was appendicitis and she had surgery."

A few days later, a rep for the couple told PEOPLE de Rossi was home and "doing well."

Appendicitis is a common condition in which the lining of the appendix is blocked and becomes inflamed, per the Mayo Clinic. It causes intense pain, and if not treated quickly — typically with surgery to remove the appendix — the organ can burst.

RELATED VIDEO: Portia de Rossi Rushed to Hospital by Ellen DeGeneres for Appendicitis Surgery

During a monologue on her talk show later that month, DeGeneres detailed the experience, saying she wasn't able to stay with the actress in the hospital due to the COVID-19 pandemic.

"That's upsetting to me. They sent me home and I'm crying," she said, quipping, "Because someone was chopping onions at the nurse's station."

DeGeneres also joked that de Rossi's pain was so severe that she offered to exchange tickets to The Ellen DeGeneres Show for more pain medication, which didn't work because "that's the rules."