The soap opera premiered Nov. 8, 1965

By Michele Corriston
Updated August 27, 2015 02:50 PM
Christopher Polk/Getty

In 50 years, the Horton and Brady families have seen countless steamy kisses, dramatic breakups and near-death experiences.

NBC is paying homage to Days of Our Lives‘ fifth decade on the air this fall, and PEOPLE has an exclusive first look at the soap opera’s big anniversary.

Days premiered Nov. 8, 1965, and is one of the longest-running TV shows in history. The series counts Alison Sweeney, Eileen Davidson and John Aniston (Jennifer‘s father!) among its famous alumni, and actors like Suzanne Rogers have called its set home for most of their careers.

Watch some of the best moments in the video above. Days of Our Lives airs weekdays on NBC.