Entertainment TV A History of Brooke Mueller's Personal and Legal Struggles Brooke Mueller's stints in rehab and drug-related arrests have checkered her relationship with ex-husband Charlie Sheen and the pair's twin boys By Alex Heigl Updated on November 17, 2016 05:37 PM Share Tweet Pin Email Brooke Mueller and Charlie Sheen’s twin sons are safe at home after being reported missing Wednesday morning, a source has confirmed to PEOPLE. “Brooke went off of her medications,” the source confirmed, and has since been hospitalized. Mueller has struggled for years with substance abuse and mental health issues after landing small roles in film and television in the late ’90s and early ’00s, notably alongside friend Paris Hilton in her own reality show. Below, a brief timeline of Mueller’s ups and downs. January 2010 Nearly seven years ago, Mueller dealt with a health scare that delayed a hearing on her domestic violence case with Sheen: She had to have a wisdom tooth removed, and was later rushed to intensive care overnight with a 105-degree fever that developed as a result from the removal. Her hospitalization threw a wrench into the couple’s court case that was thrown into motion when Sheen was arrested for domestic violence on Christmas Day 2009. Mueller was released from the hospital — with her list of ailments upgraded to include pneumonia — on Jan. 26, 2010. A day later, it was revealed that Mueller had checked into a North Carolina “wellness program,” which her lawyer, Yale Galanter at the time vehemently refused to describe as drug rehab. “I insisted she come with me for some stress reduction based on suggestions from her doctors,” Mueller’s mother Moira Fiore told PEOPLE as well. “I don’t want my daughter to have a nervous breakdown.” Getty(2) February 2010 A month to the day after she left the hospital, multiple sources were confirming that Mueller had checked into Malibu, California’s The Canyon rehab facility. It was reported that she had been seen out partying with Charlie Sheen hours before entering the facility. “It is the best thing of for her to do,” a source told PEOPLE. “She really liked the programs in North Carolina and would like to go back there at some point.” May 2010 By May, the two were denying through reps that they were seeking a divorce. Shortly after Mueller completed her 90-day stint in rehab, she moved into a separate dwelling from Sheen. A source at the time said she was “basically taking a break from the marriage,” but in May, they were claiming that they simply needed privacy and distance to work through their problems. August 2010 Three months later, the police report from the Christmas Day 2009 fight was released, and contained in it the jarring assertion from Sheen that Mueller had become physical with him because of, partly, the song “Drops of Jupiter” by the band Train. The innocuous hit was apparently one of Sheen and his daughter’s favorite songs, and that fact, along with Sheen’s purchase of two telescopes for himself and his daughter (to stargaze together), apparently drove upset Mueller to the point that the pair’s argument became physical. October 2010 Sheen was hospitalized a few months later in New York. Police sources claim they found the then-45-year-old actor intoxicated in his hotel room; Sheen’s rep claimed he had an allergic reaction to medication. A few days later, on Nov. 1, it was revealed that the pair were divorcing, with Mueller filing for primary physical custody of their twins. December 2010 Mueller checked into a sober living facility as the year closed out shortly after filming an appearance in Paris Hilton’s short-lived reality show The World According to Paris Hilton. February 2011 By February, Mueller had moved back in with Sheen temporarily while she and the couple’s twins, Max and Bob, got ready to move into the new house Sheen bought for them down the street. March 2011 Early the next month, motivated by Sheen’s increasingly erratic behavior — which included an interview with 20/20 in which he stated “I am on a drug. It’s called Charlie Sheen” — that would see CBS cancel his hit show Two and a Half Men, Mueller was awarded a restraining order against Sheen. Around that time, a bombshell of a statement from Mueller dropped in Los Angeles court. Aside from allegations that Sheen knocked her unconscious before their Christmas Day 2009 fight, the statement made references to Sheen requesting a large sum of “untraceable cash to ‘knock off a few people'” and referring to his manager Mark Berg as a “stoopid Jew.” Mueller also revealed that Sheen told her “I should have killed you when I had the chance” after their fight on Christmas Day. December 2011 Mueller was arrested in December for cocaine possession and assault in Aspen, Colorado. A little over a week later, her rep revealed to PEOPLE that she had checked herself into a long-term, in-patient treatment center to address her problems with sobriety. December 2012 About a year later, it was revealed that Mueller was, despite her other struggles, successfully navigating the San Fernando Valley real estate market, flipping a house she’d purchased from former Spice Girl Mel B for a $500,000+ profit. Kevin Mazur/WireImage; X17online May 2013 But bad news returned in 2013: L.A.’s Child and Family Services removed Bob and Max from Mueller’s home early in May, and Sheen’s ex Denise Richards was granted temporary custody of the pair. Mueller was reportedly not happy about the decision, but remained at the Betty Ford Clinic to complete her course of treatment. November 2015 In the wake of Sheen’s 2015 revelation that he was HIV-positive, Mueller said in November 2015 that she and the twins were not, and as of September 2015 she and Sheen had been “getting along fantastically.” April 2016 This good will apparently dried up by April 2016, when Mueller filed documents alleging Sheen owed her $89,000 in back child support. For Sheen, it was simply another log on the pile — he’d been sued by Richards in January for $1.2 million in back child support. Then, in May, Mueller checked herself back into rehab. RELATED VIDEO: Brooke Mueller Is Seeking Treatment In A Rehab Center In the wake of Mueller’s November 2016 meltdown, Sheen addressed the situation in a bizarre poem issued exclusively to PEOPLE. “In the face of a roughshod and polar moment of unsanctioned divide, sanity and certainty were restored with grace and resolve,” he wrote, in part, before referring to his family as “his safe and stable brood.” Mueller has yet to comment on the incident.