The E! show returns Tuesday

Updated May 10, 2016 04:25 PM
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The Botched doctors are almost back, and they say things are more challenging than ever.

Season 3 of the E! show, which premieres Tuesday, features a number of patients Dr. Terry Dubrow and Dr. Paul Nassif turned away in earlier seasons, saying the procedures they were requesting were too dangerous. But some of those patients went elsewhere for treatment – and are now suffering, say the doctors.

“Some of those who chose to ignore our advice actually now have disasters. Real, significant disasters,” Dubrow, 57, tells PEOPLE. “You’re going to see people we turned down, went elsewhere and they’re back and they are really disabled.”

Among the patients returning is Rajee Narinesingh, a transgender woman who bought cement-like filler to inject into her lips and cheeks on the black market. Her face is warped from the procedure, and the woman who gave her the injections was sentenced to jail.

RELATED VIDEO: What Was the Last Gift Botched Star Terry Dubrow Gave His RHOC Wife Heather?

“Based on new experiences, we have redefined what is impossible,” Dubrow says of working with Narinesingh. “And we devised a plan that was out-of-the-box thinking that we thought might help her, and much to our great risk and potentially hers, we formulated a plan. She agreed on it.”

In addition to Botched, Dubrow and Nassif have a spinoff, Botched by Nature, due out Aug. 9 on E! The series has them help people who have congenital deformities or are the victims of accidents. He says he s learned a lot about his friend from the experience – maybe more than he wanted!

“We go out on the road as kind of a road trip bromance thing. I have learned things about Paul that no guy should know about any other guy,” jokes Nassif, 53. “So our relationship is expanded and now I am convinced he is sort of the third one to the left in the evolutionary chain. He is part monkey. There is no doubt about it.”

Joking aside, Nassif says he feels good about the cases they are taking on.

“These are cases where I don’t know any other doctors who would probably do these patients,” says Nassif. “These patients have nowhere else to go and their lives are miserable. They are willing to take a chance and a risk of having a complication.”

Botched season 3 premieres Tuesday at 9 p.m. ET on E!