Sean Penn

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Sean Penn and Wife Leila George Have a Date Night at VAX Live Event Taping

Sean Penn introduced Pearl Jam frontman Eddie Vedder, who performed two songs, during the taping of Global Citizen's VAX Live: The Concert to Reunite the World at SoFi Stadium in Inglewood, California

Meghan Markle, Prince Harry, Joe Biden and More to Appear at Global Citizen's Vax Live: The Concert to Reunite the World

First Lady Dr. Jill Biden and Vice President Kamala Harris will also appear at the star-studded event hosted by Selena Gomez, which aims to encourage people to get a COVID-19 vaccine and increase their accessibility worldwide

More Sean Penn

Brad Pitt Joins Jennifer Aniston in Live Table Read of Fast Times at Ridgemont High

Julia Roberts, Sean Penn and Matthew McConaughey will also star in the reading of the 1982 classic, benefitting COVID-19 relief

WATCH: Ava DuVernay, Chris Evans, Mark Ruffalo and More Celebrate Indigenous Youth Graduation

The event was organized by Protect the Sacred, the grassroots initiative created in response to the COVID-19 pandemic on the Navajo Nation