Credit: Adam Taylor

8-9 PM · Fox · Debuts Sept. 16

Accidentally get your best buddy’s girlfriend killed and there will be consequences. Season 5 picks up a few months after Amber (Anne Dudek) died trying to retrieve a drunken House (Hugh Laurie), causing Wilson (Robert Sean Leonard) to question his ties to the hospital — and to House. ”I don’t want to terminate that relationship, I want to challenge it,” says series creator David Shore, hinting that the frost will eventually thaw. Things are heating up, however, between House and Cuddy (Lisa Edelstein), who’ve flirted for so long, says exec producer Katie Jacobs, ”it’d be unnatural for them not to get close.” But not too close, okay? If House got happy, we wouldn’t recognize the guy.