May 22, 2014 09:25 AM

Alberto E. Rodriguez/Getty

Is Drew Barrymore destined only to have daughters?

Maybe so, she says. But she’d love to have a boy, even if she’d probably be totally lost at first.

“I feel like if my husband and I try to have a third, I would be mystified if we have a boy, because I’m so unfamiliar with boys,” the actress and mother of two daughters — Olive, 20 months, and Frankie, 4 weeks — told PEOPLE at the Hollywood premiere of her new movie, Blended, on Wednesday.

In the film, Barrymore, 39, plays the mother of two boys, but that didn’t even help. “I’m totally still as stupefied as ever!” she claims.

“I’m a guy’s girl, and I’ve never been overly ‘girlie-girl,’ but I love my girlfriends so much, so it makes all the sense in the world that my karma is to have two daughters,” she says.

“I have such an Achilles heel with the mother-daughter relationship. I just get girls.”

And yet, she adds, “I love men, and I feel like I would have a lot to learn from my son if I was ever lucky enough to have a boy.”

Asked how it’s been juggling her schedule with two kids now, including a newborn, Barrymore says she and husband Will Kopelman have it totally under control.

“Will is a great father!” she says. “He is amazing, and we all have each other’s backs. When anybody has to do something, somebody is there to fill in. We also spend all of our time together.”

“Listen, it’s two to three weeks of work,” she says of promoting the movie, “and I’m going to be back in sweatpants until November! I am literally never without my family. My kids go with me everywhere, I’m a stay-at-home mom, I’m a work-from-home mom a lot of the time, so to get out for a couple of weeks is actually kind of okay!”

— Tim Nudd with reporting by Reagan Alexander

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