Reese Witherspoon's Famous Friends: From Paul Rudd to Oprah Winfrey

This selfie is proof that these two don't age (and that they've been buddies since 1996). The two also went on to costar in the 2010 rom-com How Do You Know?

The Big Little Lies costars are friends on- and off-screen, with Kidman telling E! News, "We have so much in common and we're very close. I'm lucky to have her as such a good friend." 

On her friend's birthday in 2019, Witherspoon captioned a photo of the pair on the red carpet, "Happiest birthday to one of the most radiant gals around! 💫⚡️🌟It is a privilege to call you a friend & producing partner. Love you @NicoleKidman! 💖" In 2020, she called Kidman her "Australian sister," adding "I'm so lucky to have you in my life...learning and laughing with you!" 

These gal pals met in 2011, and Dern played Witherspoon's mom in Wild! The pair stayed close and continued to collaborate. 

Dern told The New York Times in 2017, "When I met Reese, I knew she would be my family for the rest of my life. And I don't say that lightly."

The friends, who also costarred on Big Little Lies, can't stay away from each other. Even amid the coronavirus pandemic, the pair went for a socially distanced hike together. 

Kravitz told Elle of her Big Little Lies co-star, "Reese Witherspoon would win one of my top-five favorite human awards. She's so honest. She's so funny. And she's fiery as hell. Her ferocity and care for everybody in her life is through the roof. I strive to be a friend like her." 

Meanwhile Witherspoon wrote of Woodley on Instagram, "One of [her favorite things] is getting to hang out with this talented lady every day!"

The Little Fires Everywhere costars are close pals, and have been for quite some time. Even before they shared the screen, Witherspoon was gushing about Washington on Instagram. She wrote in 2016, " "My friend and one of my favorite actresses/ producers/ mothers/ philanthropists, this woman is a champion for change in the world in so many ways...(Not to mention she's smokin' hot!)🔥🔥🔥"

Washington told Variety, "In the real world, Reese and I are not supposed to be friends. I grew up in the Bronx a block away from the projects, and she grew up in Nashville, Tennessee," but somehow the pair are a match made in Hollywood heaven. 

These two became close while filming A Wrinkle In Time and didn't stop there! Witherspoon made a cameo on The Mindy Project, Kaling had a recurring role in The Morning Show and the pair will be teaming up again for Legally Blonde 3, which Kaling is co-writing. Talk about a power friendship! 

As two of the nicest actresses in Hollywood, it's no wonder that Jennifer Garner and Reese Witherspoon are pals. Garner even broke out her saxophone to play Witherspoon a birthday song, captioning her video, "Many moons ago, my high school marching band played this song for homecoming. Today I play it for my boo, @reesewitherspoon. ♥️We have a groovy kind of love.♥️ Happy birthday, Lady."

They may not be having mommy-and-me playdates with Blue Ivy and Tennessee, but Witherspoon definitely considers Beyoncé a "really good" friend.

After Witherspoon asked Queen Bey herself for some champagne at the 2020 Golden Globes and Bey obliged, Witherspoon joked with Ellen DeGeneres, "Beyoncé and I are really good friends. I mean, really, really, really, good friends. In fact, you might say, 'Best friends.' Some might say that." 

Beyoncé also sent over a case of champagne and her Ivy Park collection, which Witherspoon showed off on Instagram.