MTV Movie and TV Awards 2021 Best Moments

As the night's host, the actress and comedian seriously brought the energy with an opening that saw her dropped into series like WandaVision and subsequent sketches in which she played a stripper trying to seduce the icons of One Night in Miami, Daphne Bridgerton on her wedding night (yup, she burned for him) and a neighbor annoyed at the noise caused by Godzilla vs. Kong. In her opening monologue, she touched on getting back into the dating scene post-pandemic ("You cannot ghost a Ghostbuster!") and as a big bonus, she picked up the award for best comedic performance for her role in Coming 2 America.

Of the 13 awards, the Disney+ fave picked up four: best show, best performance in a show for star Elizabeth Olsen, best villain for Kathryn Hahn and best fight for a Wanda vs. Agatha duel.

Accepting the Generation Award for her 30-plus-year career in Hollywood, the actress gave a heartfelt speech that was hilariously interrupted by her husband, Colin Jost, who mistook the moment for the Nickelodeon Kids' Choice Awards and slimed her. 

"What the f---!" she shouted, as Jost said with a smile, "MTV! 'You got slimed!' " The actress then said, "That's Nickelodeon!"

"I'm very, very sorry," said the Saturday Night Live star. "I'll get a towel. ... Love you."

Accepting the Comedic Genius Award remotely, Cohen whipped up a little movie magic, starting his acceptance speech as Borat, who was interrupted by Ali G, who was usurped by Cohen himself, who was then cut off by Brüno (got all that?).

"I am officially canceling myself," Cohen joked to the audience before he stepped off the stage. "I was actually really looking forward to this after losing the Oscar. You can f---ing keep it."

The actor, who died last August at age 43, won yet another award for his role as Levee in Ma Rainey's Black Bottom: best performance in a movie. Presenter Yara Shahidi accepted the award on Boseman's behalf; earlier in the year, the late actor was honored with Golden Globe and Screen Actors Guild Awards for his performance.