KEANU REEVES & WINONA RYDER
Over 20 years after appearing together in 1992’s Dracula, the ’90s darlings are returning to the big screen once more as a socially awkward pair en route to a destination wedding in the upcoming film titled — you guessed it — Destination Wedding. “As a fan, I have such longstanding love for both of them and for their work, so it feels really good to see them together again,” director Victor Levin told PEOPLE of working with the onscreen couple. “And as a filmmaker, I have the benefit of their having known each other for so long. They have superb natural chemistry together, which is so important for a love story.”
RYAN GOSLING & EMMA STONE
We knew it was just a matter of time until we saw Gosling and Stone back at it on the big screen. Following their memorable scenes in 2011’s Crazy, Stupid, Love. (read: Gosling’s unforgettable abs), the duo again channeled their undeniable chemistry in the 2013 drama Gangster Squad. The pair reunited once more in 2016’s La La Land, which earned Stone her first-ever Oscar.
BRAD PITT & ANGELINA JOLIE
By the Sea (2015) marked the second time Jolie and Pitt have played a couple; the first was in 2005’s Mr. and Mrs. Smith. The stars’ most recent effort found them in a much darker place than their first endeavor, with the estranged couple taking on the roles of husband and wife in a strained relationship.
LEONARDO DICAPRIO & KATE WINSLET
RICHARD BURTON & ELIZABETH TAYLOR
Though their relationship was famously tumultuous off-screen, the pair went on to star in 11 films together throughout their careers. Their first, Cleopatra (1963), sparked their romantic relationship and Who’s Afraid of Virginia Woolf? (1966) gave audiences an eerily real look at a bitter aging couple.
RICHARD GERE & JULIA ROBERTS
They rescued each other at the end of Pretty Woman (1990) and reunited in Runaway Bride (1999), in which they fell in love all over again. Predictable? Maybe. Were we captivated each time? You bet. We can watch these two all day.
BRADLEY COOPER & JENNIFER LAWRENCE
Although the stars deny any off-screen romance, Cooper and Lawrence’s on-screen chemistry was at an all-time high in Silver Linings Playbook (2012) and Serena (2014). (The two also appeared on the big screen together in 2013’s American Hustle and 2015’s Joy, though they didn’t play couples in these movies.)
KEANU REEVES & SANDRA BULLOCK
JAKE GYLLENHAAL & ANNE HATHAWAY
Talk about emotionally draining! Instead of opting for the comedic route, Gyllenhaal and Hathaway turned to dramatic roles in Brokeback Mountain (2005) and Love & Other Drugs (2010). While Brokeback focused on a one-sided love affair, Love & Other Drugs offered us a look at a young couple facing an unfortunate diagnosis.
TOM HANKS & MEG RYAN
Evidently, the fourth time is the charm for Hanks and Ryan, who are set to make their highly anticipated return as an on-screen couple in Ryan’s directorial effort Ithaca. We first got a glimpse at their chemistry in Joe Versus the Volcano (1990), then again in Sleepless in Seattle (1993) and You’ve Got Mail (1998). And if Ithaca is anything like its predecessors, we’re bound for some serious movie magic (and possibly some tears).
ADAM SANDLER & DREW BARRYMORE
So nice, they had to work together thrice! After melting our hearts in 1998’s The Wedding Singer, these two off-screen friends reunited for 2004’s adorable 50 First Dates and 2014’s Blended.
PAUL RUDD & REESE WITHERSPOON
After watching Overnight Delivery (1998), there was no question about it: Rudd and Witherspoon belonged together – at least on the big screen. Enter How Do You Know, a 2010 comedy that made us fall in love with both actors all over again.
OWEN WILSON & RACHEL MCADAMS
MATTHEW MCCONAUGHEY & KATE HUDSON
BEN AFFLECK & JENNIFER LOPEZ
While 2003’s Gigli proved to be a box office fail, the then-engaged duo gave it another go in 2004’s Jersey Girl, in which they played husband and wife – roles we never got to see them play together in real life since they split shortly before the film’s release.
TOM CRUISE & CAMERON DIAZ
DIANE LANE & RICHARD GERE
So nice, they had to do it thrice! After starring together in 1984’s The Cotton Club, Lane and Gere reunited for the 2002 thriller Unfaithful and again in 2008’s Nights in Rodanthe. “Third time’s the charm, and the chemistry is still there,” the actress said in an interview.