The Chemistry Is Palpable: 17 Pairs Who've Played On-Screen Couples More than Once

These stars just can't seem to quit each other – and we're not complaining

01 of 17

KEANU REEVES & WINONA RYDER

winona-ryder
Everett; Robb Rosenfeld

Over 20 years after appearing together in 1992's Dracula, the '90s darlings are returning to the big screen once more as a socially awkward pair en route to a destination wedding in the upcoming film titled — you guessed it — Destination Wedding. "As a fan, I have such longstanding love for both of them and for their work, so it feels really good to see them together again," director Victor Levin told PEOPLE of working with the onscreen couple. "And as a filmmaker, I have the benefit of their having known each other for so long. They have superb natural chemistry together, which is so important for a love story."

02 of 17

RYAN GOSLING & EMMA STONE

emma-stone
Everett; Courtesy Warner Brothers/Everett Collection; Wilson Webb/Warner Bros

We knew it was just a matter of time until we saw Gosling and Stone back at it on the big screen. Following their memorable scenes in 2011's Crazy, Stupid, Love. (read: Gosling's unforgettable abs), the duo again channeled their undeniable chemistry in the 2013 drama Gangster Squad. The pair reunited once more in 2016's La La Land, which earned Stone her first-ever Oscar.

03 of 17

BRAD PITT & ANGELINA JOLIE

BRAD PITT & ANGELINA JOLIE
Stephen Vaughn/SMPSP;Universal Pictures

By the Sea (2015) marked the second time Jolie and Pitt have played a couple; the first was in 2005's Mr. and Mrs. Smith. The stars' most recent effort found them in a much darker place than their first endeavor, with the estranged couple taking on the roles of husband and wife in a strained relationship.

04 of 17

LEONARDO DICAPRIO & KATE WINSLET

LEONARDO DICAPRIO & KATE WINSLET
Courtesy Paramount Pictures; Courtesy Dreamworks

We'll never let go. While DiCaprio and Winslet's Titanic (1997) made us believe in true love, the stars' struggles in Revolutionary Road (2008) had us rethinking marriage altogether. Proof of brilliant acting? We think so.

05 of 17

RICHARD BURTON & ELIZABETH TAYLOR

RICHARD BURTON & ELIZABETH TAYLOR
Silver Screen Collection/Getty ;SNAP/ZUMAPRESS.com

Though their relationship was famously tumultuous off-screen, the pair went on to star in 11 films together throughout their careers. Their first, Cleopatra (1963), sparked their romantic relationship and Who's Afraid of Virginia Woolf? (1966) gave audiences an eerily real look at a bitter aging couple.

06 of 17

RICHARD GERE & JULIA ROBERTS

RICHARD GERE & JULIA ROBERTS
Ron Batzdorff/Buena Vista; Courtesy Paramount/Everett Collection

They rescued each other at the end of Pretty Woman (1990) and reunited in Runaway Bride (1999), in which they fell in love all over again. Predictable? Maybe. Were we captivated each time? You bet. We can watch these two all day.

07 of 17

BRADLEY COOPER & JENNIFER LAWRENCE

BRADLEY COOPER & JENNIFER LAWRENCE
Courtesy The Weinstein Company; Courtesy 2929 Productions/Chockstone Pictures/Nick Wechsler Productions

Although the stars deny any off-screen romance, Cooper and Lawrence's on-screen chemistry was at an all-time high in Silver Linings Playbook (2012) and Serena (2014). (The two also appeared on the big screen together in 2013's American Hustle and 2015's Joy, though they didn't play couples in these movies.)

08 of 17

KEANU REEVES & SANDRA BULLOCK

KEANU REEVES & SANDRA BULLOCK
SNAP/Rex/REX USA; Peter Sorel

Blame Speed's adrenaline-filled scenes for the romantic tension we felt between the actors in the 1994 film; it made us long for more Reeves and Bullock. We finally got our wish when 2006's fantasy film The Lake House premiered in theaters.

09 of 17

JAKE GYLLENHAAL & ANNE HATHAWAY

JAKE GYLLENHAAL & ANNE HATHAWAY
Focus Films/Everett Collection;Courtesy Everett Collection

Talk about emotionally draining! Instead of opting for the comedic route, Gyllenhaal and Hathaway turned to dramatic roles in Brokeback Mountain (2005) and Love & Other Drugs (2010). While Brokeback focused on a one-sided love affair, Love & Other Drugs offered us a look at a young couple facing an unfortunate diagnosis.

10 of 17

TOM HANKS & MEG RYAN

TOM HANKS & MEG RYAN
Jane O'neal/Warner Bros./Getty Images; Warner Brothers/Courtesy Everett Collection

Evidently, the fourth time is the charm for Hanks and Ryan, who are set to make their highly anticipated return as an on-screen couple in Ryan's directorial effort Ithaca. We first got a glimpse at their chemistry in Joe Versus the Volcano (1990), then again in Sleepless in Seattle (1993) and You've Got Mail (1998). And if Ithaca is anything like its predecessors, we're bound for some serious movie magic (and possibly some tears).

11 of 17

ADAM SANDLER & DREW BARRYMORE

ADAM SANDLER & DREW BARRYMORE
Courtesy New Line Cinema/Photofest; Courtesy Sony Pictures; Courtesy Warner Bros

So nice, they had to work together thrice! After melting our hearts in 1998's The Wedding Singer, these two off-screen friends reunited for 2004's adorable 50 First Dates and 2014's Blended.

12 of 17

PAUL RUDD & REESE WITHERSPOON

PAUL RUDD & REESE WITHERSPOON
Courtesy New Line Cinema/Everett Collection;Courtesy Columbia

After watching Overnight Delivery (1998), there was no question about it: Rudd and Witherspoon belonged together – at least on the big screen. Enter How Do You Know, a 2010 comedy that made us fall in love with both actors all over again.

13 of 17

OWEN WILSON & RACHEL MCADAMS

OWEN WILSON & RACHEL MCADAMS
New Line Cinema/Courtesy Everett Collection; Courtesy Sony Pictures Classics

One viewing of Wilson and McAdams in Wedding Crashers (2005) will reignite your love of rom-coms – and leave you hanging for more of the pair, which is where 2011's Midnight in Paris comes in.

14 of 17

MATTHEW MCCONAUGHEY & KATE HUDSON

MATTHEW MCCONAUGHEY & KATE HUDSON
Courtesy Paramount/Everett Collection; Courtesy Warner Bros.

Although in 2003 Hudson's Andie Anderson aimed to lose McConaughey's Ben Barry in 10 days, we're so glad she kept him as her love interest in 2008's Fool's Gold.

15 of 17

BEN AFFLECK & JENNIFER LOPEZ

BEN AFFLECK & JENNIFER LOPEZ
Courtesy Sony;James Devaney/WireImage

While 2003's Gigli proved to be a box office fail, the then-engaged duo gave it another go in 2004's Jersey Girl, in which they played husband and wife – roles we never got to see them play together in real life since they split shortly before the film's release.

16 of 17

TOM CRUISE & CAMERON DIAZ

TOM CRUISE & CAMERON DIAZ
GIG/Getty Images;Frank Masi

Diaz and Cruise starred in 2001's trippy Vanilla Sky, which saw both stars in roles way out of their comfort zones (i.e. There's Something About Mary and Mission: Impossible). They reunited for something a little more their speed in 2010: the action-packed Knight and Day.

17 of 17

DIANE LANE & RICHARD GERE

gere-lane-2000
Zoetrope/Orion/REX/Shutterstock; Barry Wetcher/New Regency/REX/Shutterstock; Michael Tackett/Warner Bros./REX/Shutterstock

So nice, they had to do it thrice! After starring together in 1984's The Cotton Club, Lane and Gere reunited for the 2002 thriller Unfaithful and again in 2008's Nights in Rodanthe. "Third time's the charm, and the chemistry is still there," the actress said in an interview.

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