Sarah Paulson, Rosie O'Donnell and More Stars to Chat with Cancer Patients for Charity Streaming Event

The charity event will be streamed exclusively on PEOPLE platforms Thursday night

Step aside, late-night hosts, because your favorite celebrities are about to be guests on an all-new type of talk show — and all for a good cause.

Stars like Sarah Paulson, Jim Gaffigan, Rosie O’Donnell and more are stepping into the hot seat to chat with cancer patients for a one-night-only charity event benefiting The Creative Coalition.

The nonprofit’s event, titled The Creative Coalition Fantasy Talk Show Special, will stream exclusively on, PeopleTV, and PEOPLE’s Facebook, Twitter and YouTube pages on Thursday at 5 p.m.PT/8 p.m. ET.

Paulson, Gaffigan, O’Donnell, Tim Daly, Edie Falco, Zachary Levi, Bob Saget, Iliza Shlesinger and Aisha Tyler will sit down with patients living with glioblastoma, a rare brain cancer, for a series of candid conversations.

Paulson, for example, will chat with patient Kathleen Straub-Jones on The Kate the Great Show, spilling plenty of details on how she got into acting, her career regrets and what’s next for the star.

Sarah Paulson, Rosie O'Donnell
Sarah Paulson; Rosie O'Donnell. Steve Granitz/WireImage; Vera Anderson/WireImage

The special, which is sponsored by Novocure and produced by actor and producer Erich Bergen, will also feature a special performance by Grammy-nominated musician MAJOR.

Surprise guests from the music, TV and film worlds will also make appearances throughout the night.

“It’s going to be an extraordinary night of art bringing the human touch back into events,” The Creative Coalition CEO Robin Bronk said in a statement. “The Creative Coalition Fantasy Talk Show underscores how the Arts bring back a 3-D human, soulful, and emotional experience into today’s gatherings.”

The Creative Coalition, of which Daly is the president, was founded in 1989 and is “dedicated to using the power and platform of the arts and entertainment communities in award-winning public service advocacy campaigns.”

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