'Botched' Doctors Take on Their Biggest Challenge Yet Helping People with Birth Defects in 'Botched By Nature'

"Once we started getting new skills and experiences based on Botched, we realized we could apply these things to problems that were even more difficult," Dr. Terry Dubrow tells PEOPLE

Photo: D Dipasupil/FilmMagic

Drs. Terry Dubrow and Paul Nassif are expanding their clientele in the new show Botched By Nature, premiering on E! on August 3.

Rather than performing surgery on people whose previous cosmetic procedures have gone wrong, the doctors will help people who have been born with birth defects, or who have survived traumatic accidents. And they’re traveling all over the country to meet with their clients for consultations in their home settings.

“Once we started getting these new-level skills and experiences based on three seasons of doing Botched, we realized we could apply these things to problems that were even more extraordinarily difficult,” Dubrow, 57, tells PEOPLE. “We thought the only way to really appreciate and understand how the problems have affected these people’s lives was to get into their worlds, and go meet them and their families.”

The show takes the doctors to small towns where people may not have access to plastic surgeons or specialists needed to fix their physical issues.

The doctors meet the patients and their families and immerse themselves in small-town life, “whether it’s eating squirrels or riding on the backs of alligators,” says Dubrow. “Then we determine if we can help them, and if we can, we bring them back to Los Angeles and try to correct their deformities,” he explains.

During their journey across the country, Nassif, 54, encountered “the hardest reconstruction of my career,” he tells PEOPLE. “The patient has what we call a vasculitis disease, or a disease that involves the small blood vessels, and I do a nasal reconstruction on this patient. I don’t want to give too much away, but it actually eats me up.”

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Dubrow’s most challenging patient was a formerly conjoined twin who was left without buttocks after being separated.

“There’s no textbook for how to make a buttock, there’s no instructional manual,” he says. “You just have to take your experience and use it in a novel, creative way in order to try to do something that essentially no one’s ever done before.”

Another patient survived two tours of Iraq, but got strike by lightning when they returned home.

“That’s a crazy example of being botched by nature, truly!” says Dubrow.

Dubrow also clarified that the show is not deriding anyone who was born with a birth defect.

“It’s really not about saying they’re ‘botched,’ but using the experience and skillset from Botched to help people who have been affected adversely by nature,” he says. “We’re trying to help them with a problem that they’ve had for a long time, that’s had a very profound effect on their lives. That’s really what it’s all about.”

Botched By Nature premieres August 3 at 9 p.m. ET/PT on E!