It's been 20 years since the 1987 debut of thirtysomething, but the ABC hit's four female stars – Polly Draper, 51, Mel Harris, 50, Melanie Mayron, 54, and Patricia Wettig, 55 – are as close as ever. Reunited as ambassadors for Tylenol's Keep Moving arthritis-prevention campaign, the women sat down with PEOPLE's Pamela Warrick to talk about how they're looking great as fiftysomethings.
(More information on the Keep Moving program, a joint venture launched by Tylenol and the Arthritis Foundation to educate Baby Boomers about ways to ease the aches and pains of aging, is available at justkeepmoving.com.)
Played: Happily married Hope Murdoch Steadman Now: The mom of two (Byron, 23, and Madeline, 17) remains a TV regular, appearing on shows like Criminal Minds, and says, "I believe in love," despite being in the midst of a fifth divorce. Facing facts: "I can certainly, honestly say, I do visit my dermatologist. Regularly!"
Played: Stay-at-home mom Nancy Krieger Weston Now: Wettig, who's been married to thirtysomething costar Ken Olin for 25 years, stars on Brothers amp Sisters, which Olin executive produces; their son Cliff, 24, is one of the show's writers while daughter Roxy, 21, has a small recurring role as Michelle. Gray matter: "If I was a farmer, I'd have a long gray ponytail. But I wouldn't show up today with gray roots. If everybody is having surgery and you haven't, you look old."
Played: Confused career woman Ellyn Warren Now: Draper has been married to musician Michael Wolff since 1992, and has two sons, Nat, 12, and Alex, 9, whom she directs in Nickelodeon's The Naked Brothers Band. Jump start: I run three miles a day, wherever I am. I also do weights and I jump rope. Twenty years ago, I started jump roping because you can take a jump rope anywhere."
Played: Free-spirited photographer Melissa Steadman Now: Mayron is a single mom to twins Miles and Olivia, 8, and is getting set to launch a diaper cream later this year. Personal uplift: "I've still got my pregnancy weight from years ago, the final 20 lbs. I haven't lost! I had my breasts reduced and lifted last year. After the babies, they just ... needed it."
For more from the women of thirtysomething, including the secrets to a happy marriage and how it feels to grow older in Hollywood, check out the new issue of PEOPLE, on newsstands now