Hollywood Breakups 2012: Tom & Katie, Johnny & Vanessa, Heidi & Seal

KATIE & TOM

The split between Cruise and Holmes sent shock waves through the celebrity world when the actress filed for divorce five days before Cruise's 50th birthday in June 2012. Though the actor said he was blindsided and "deeply saddened" by the split, he and Holmes remained tight-lipped about what could have been an explosive legal battle, instead quietly coming to a settlement that focused on the best interest of their 9-year-old daughter, Suri.

02 of 25

HEIDI & SEAL

After seven years of marriage, Klum and Seal announced they were separating in 2012, with the supermodel telling PEOPLE, "We have had the deepest respect for one another throughout our relationship and continue to love each other very much, but we have grown apart." The stars finalized their divorce in 2014.

03 of 25

JENNIE & PETER

Beverly Hills, 90210 star Jennie Garth, 40, and Twilight patriarch Peter Facinelli, 39, had three daughters, ages 5 through 14, over their 11 years of marriage, and their children were foremost on their minds when they announced in March that they were divorcing. "We're very dedicated to being great parents," Facinelli told Kelly Ripa in April. True to his word, Facinelli got a glowing shout-out on Father's Day from Garth, who Tweeted, "Our girls are so lucky to have a daddy like you! Hope you have a great day with them:)@peterfacinelli."

04 of 25

BETHENNY & JASON

Just days before Christmas in 2012, Real Housewives of New York City's Frankel and Hoppy announced they were parting ways after nearly three years of marriage. The couple, who are parents to daughter Bryn, 5, are currently finalizing property negotiations. Looking back on their relationship, the Skinnygirl mogul says she had an instinct that her marriage would end in divorce. "I could feel it, but I intellectualized it," she recently said. "People are always talking about, 'Do I go with my head or my heart?' Go with your gut."

05 of 25

CHRIS & GWEN

While he's watched plenty of couples unite and then split over 16 seasons of The Bachelor, the biggest surprise came when host Chris Harrison announced the breakup of his own marriage in May. After 18 years of marriage and two children, Harrison, 40, and wife Gwen said in a joint statement, "Though we have made this incredibly difficult decision to separate, our love and mutual respect remain, and we look forward to sharing in the lives of our wonderful children."

06 of 25

DANICA & MIKE

The Wonder Years really are over for McKellar, 37, who filed for divorce from her husband, composer Mike Verta, in early June. The couple married in 2009 and have a son, Draco. "Thank you so much for all your love and support during a tough time!" McKellar wrote on Twitter after the divorce announcement.

07 of 25

KIMORA & DJIMON

After five years together, designer Kimora Lee Simmons, 37, and actor Djimon Hounsou, 48, confirmed in November that their relationship was officially over. Though they never married, the fashionable pair are parents to 3½-year-old son Kenzo (Simmons also has daughters Ming, 12, and Aoki, 10, with her ex-husband Russell Simmons). "The truth is Djimon + I have been separated for some time," Simmons Tweeted about the split. "We have remained happy, loving, co-parenting friends + family. We all have much to be thankful for."

08 of 25

TAYLOR & CONOR

Look out for another post-breakup anthem from pop star Taylor Swift, 22, whose whirlwind summer romance with 18-year-old beau Conor Kennedy turned cold by autumn. After plenty of PDA throughout the Kennedy playground of Hyannis Port, Mass. – and even getting the seal of approval from family matriarch Ethel – a source at Conor's school, the Deerfield Academy, told PEOPLE, "His friends have said it's over. I have a feeling she ended it."

09 of 25

JOE & TINA

Becoming second-time grandparents wasn' t enough to save the 34-year marriage of Jessica and Ashlee Simpson's parents, Tina and Joe. The pair filed for divorce in October, after Tina cited "discord or conflict of personalities" in the court papers obtained by PEOPLE. "It is an amicable split and there is no third party involved," a rep for the family tells PEOPLE amid rumors that Joe came out to his family.

10 of 25

DENNIS & KIMBERLY

Number three wasn't quite the charm for actor Dennis Quaid, 58, whose third wife Kimberly Buffington-Quaid filed for legal separation six months after putting their divorce on hold. Though Kimberly stated in court papers that relations between the two had "become insupportable because of discord or conflict of personalities," the Vegas star will get visitation with the couple's 4-year-old twins.

11 of 25

RUSSELL & DANIELLE

Oscar winner Russell Crowe, 48, and his Aussie musician wife Danielle Spencer, 43, are reportedly no longer a couple, according to the Sydney Morning Herald. The couple's apparent split in October came after rumors of a rocky romance over the summer. The couple, who met on the 1990 movie The Crossing and married in a lavish wedding in 2003, have two sons, Charles, 8, and Tennyson, 6.

12 of 25

DANNY AND RHEA

The two comedic actors may have set a record in Hollywood for their long-lasting marriage, but no one was laughing when Danny DeVito, 67, and Rhea Perlman, 64, separated in October after 30 years together. The couple are parents to three grown children (Daniel, 25, Grace, 27, and Lucy, 29) and successfully run Jersey Films, a production company that produced movies including Pulp Fiction and Garden State.

13 of 25

BRET & KRISTI

Every rose has its thorn, indeed. The Poison rocker, 49, had been with girlfriend Kristi Gibson, 41, for more than 16 years before proposing to her in 2010. She saw him through his stroke, a brain hemorrhage and an emergency appendectomy, but in the end he called off their engagement in late July. "Although the couple have separated they remain great friends and are committed to jointly raising their two daughters," a spokesman said.

14 of 25

ASHLEE & VINCENT

Following news of her parents' divorce filing, singer Ashlee Simpson, 28, split with her boyfriend of a year and a half, Boardwalk Empire actor Vincent Piazza. The pair got together shortly after Simpson’s divorce from musician Pete Wentz, with whom she has a 4-year-old son, Bronx. A source told The New York Post's Page Six that Piazza's work schedule may be to blame, but there's hope yet: "It was a mutual agreement to split, but things have been bumpy for a little while, so perhaps they might reconcile."

15 of 25

MARCIA & THADDAEUS

Oscar winner Marcia Gay Harden, 52, filed for divorce from Thaddaeus Scheel, her husband of 15 years, in February. Harden and Scheel have three children together – 7-year-old twins Hudson and Julitta Dee, and a 13-year-old daughter, Eulala.

16 of 25

AMY & WILL

It's lights out for comedic stars Amy Poehler, 40, and Will Arnett, 42, who are calling it quits after nine years of marriage. In happier times, Arnett said he had an immediate crush on his wife, who stars in Parks and Recreation. "The first time I saw her onstage, I said, 'I'm gonna marry that girl,' " the Up All Night star told PEOPLE in 2009. The couple are parents to sons Archie, 4, and Abel, 2.

17 of 25

ADAM & ANNE

"There are men who really just love women, who think they're the most amazing people in the world. And that's me." Maroon 5 frontman Adam Levine, 33, explained to Details about his reputation for bedding women. That appreciation for women helped the Voice judge bounce back after his model girlfriend of two years, Anne Vyalitsyna, 26, ended their romance in April. By June, Levine was spotted smooching another Victoria's Secret model, Behati Prinsloo.

18 of 25

KALEY & JOSH

Kaley Cuoco, 26, of The Big Bang Theory quietly ended her engagement to addiction specialist Josh Reznik in March, saying only, "I'm not engaged anymore," but refusing to elaborate. After joking about being engaged at the 2011 Golden Globes, Cuoco was planning on tying the knot for real with Reznik after he surprised her with a proposal during a "quiet date night at home" in October 2011.

19 of 25

ADRIENNE & PAUL

Real Housewives of Beverly Hills star Adrienne Maloof, 50, and her cosmetic-surgeon husband, Paul Nassif, filed for legal separation in July, ending a tempestuous relationship whose ups and many downs were frequently caught on camera for the reality show. According to sources, the breakup was a long time coming. "The tension in the house was something that kids didn't need to hear," the source told PEOPLE of the couple's three children. "The split is the best thing for everyone."

20 of 25

MARTIN & SHAMICKA

Though they were only officially married for under two years, Big Momma's House star Martin Lawrence, 47, and wife Shamicka had been together for 15 before that, making it the end of a nearly two-decade relationship when they announced their decision to split in April. "Out of love and respect for one another we will continue to remain friends and raise our two beautiful daughters together," the couple said in a joint statement.

21 of 25

MENA & SIMONE

American Pie star Mena Suvari filed for divorce from her husband of 18 months, Simone Sestito, on Jan. 13, 2012. The 32-year-old actress declared that she'd split from the concert producer in November 2011, and cited irreconcilable differences as the reason behind the end of her marriage, her second. A year before the divorce filing, the two had talked about wanting to have two children.

22 of 25

DEBRA & DANIEL

After 10 years of marriage, Smash star Debra Messing, 44, called it quits with her actor-producer husband Daniel Zelman, 45, with whom she has a son. "I am at peace with the journey we’ve had," she said before filing for divorce in June." I feel like the 20 years we had together has been a huge success. And despite the fact that everything is changing, I think everyone is thriving." One major change for Messing – she's moved on with her costar Will Chase.

23 of 25

SINEAD & BARRY

It was a quickie Vegas marriage and an even quicker divorce for Irish singer O'Connor, 45, and her husband, Barry Herridge, whose 16-day marriage ended on Jan. 13, 2012. Though the couple briefly reunited, in the end the troubled star made it clear that she doubted she'd ever be wed again, saying on her website, "I will never again associate myself romantically with anyone."

24 of 25

DEMI & WILMER

The never confirmed on-again, off-again Disney star, 19, and Wilmer Valderrama, 31, sparked rumors that they split yet again in January 2012 when Lovato cryptically Tweeted a quote from Marilyn Monroe – "A wise girl kisses but doesn't love, listens but doesn't believe, and leaves before she is left." She also added this personal observation: "The smartest thing a woman can ever learn, is to never need a man."

25 of 25

JOHNNY & VANESSA

Though they hadn't appeared together on a red carpet in over a year, Depp, 48, and his longtime partner Paradis, 39, initially denied they were splitting when rumors first surfaced in January 2012. But by June, the couple of 14 years confirmed that they had "amicably separated." As the pair navigate this new chapter in their lives, they asked for privacy for their two children, Lily-Rose, 13, and Jack, 9.