Demi Lovato will headline Global Citizen Festival after Selena Gomez announced a break due to Lupus complications
Credit: Sara Jaye Weiss/Startraks

Demi Lovato will join the A-list lineup of Global Citizen Festival headliners after Selena Gomez announced a break to focus on her health, PEOPLE can exclusively confirm.

“The Global Citizen Festival combines music and activism in a way that inspires and affects millions around the world. I am proud to support this amazing organization’s ongoing efforts to improve global healthcare and to end extreme poverty,” said Lovato, 24, whose addition to the bill comes as she and longtime pal Nick Jonas travel the U.S. on their Future Now Tour.

This is the fifth year Global Citizen will host its annual advocacy show, which aims to move world leaders to enact policy changes regarding women’s equality, education, health, water and sanitation, environment, finance and innovation and food and hunger.

“Demi has been an incredible ambassador for global health and gender equality campaigns for many years. We are so thrilled to align her artistry and advocacy and have her join us as a headliner at the 2016 Global Citizen Festival in Central Park!” Global Citizen founder and CEO Hugh Evans said.

Fans can win tickets to the festival – taking place Sept. 24 in New York City’s Central Park – for philanthropic efforts. (Tickets can be won via lottery by earning points for taking action in one’s community, reaching out to world leaders, signing petitions or speaking up on social media. For more information, check out

Gomez was originally slated to perform alongside a star-studded lineup of Global Citizen headliners, including Rihanna, Kendrick Lamar, Metallica and the Diplo-founded EDM act Major Lazer. But last week, the “Kill ‘Em With Kindness” singer, 24, told PEOPLE exclusively that she will be taking a break to focus on her health, following struggles with anxiety and depression she’s faced due to her lupus diagnosis.

In addition to Lovato and the formidable slate of headliners, Global Citizen Festival will also feature appearances by guest performers (Usher, , Ellie Goulding and more), as well as A-list co-hosts, from Neil Patrick Harris to Priyanka Chopra.

And, the festival’s host committee will include: Olivia Wilde, Forest Whitaker, Chris Rock, Dianna Agron, Malin Akerman, La La Anthony, Camren Bicondova, Connie Britton, Rachel Brosnahan, Michael Chiklis, Andy Cohen, Monique Coleman, Amanda De Cadenet, Pete Dominick, Heather Graham, Danai Gurira, Erin Heatherton, Daymond John, Taryn Manning, Tamzin Merchant, Bridget Moynahan, Bill Nye, Aaron Paul, Kal Penn, Erin Richards, Isha Sesay, Amani Toomer, Pete Wentz and Bonnie Wright

This year, festival-goers will be able to make use of the newly launched Global Citizen Festival app (available for download for Apple and Android deices). And the show will air on MSNBC, as well as available for streaming on YouTube and beginning at 3 p.m. EST on Sept. 24.