September 11, 2006 12:00 PM

Lisa Edelstein

The actress, 40, is back for a new season as Dr. Cuddy, the dean of medicine always trying to rein in Hugh Laurie on FOX’s hit House.

ON HUGH LAURIE OFF CAMERA: He doesn’t stay in character, but he stays in American accent. It would be too difficult for him to switch back and forth. Sometimes I really miss that other guy, the English guy—he’s more relaxed.

ON WHAT HOUSE TAUGHT HER: How much of medicine is a guessing game. And to be sure you keep asking questions of doctors. Medicine can be a weapon or a lifesaver.

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