November 20, 2006 12:00 PM

James Denton

The Desperate Housewives star plays (for charity) on the game show’s annual all-star challenge, airing this month. His challengers: Neil Patrick Harris and Bebe Neuwirth.

ON HIS BEST TRIVIA SUBJECTS I tend to do really well with American history and Presidents. Of course sports is a no-brainer, pop culture—movies, TV. I have a lot of useless knowledge in my head. I’m decent at that stuff.

ON HIS COMPETITION Neil and Bebe are really smart. I convinced myself that it was because on TV he’d played a doctor [on Doogie Howser, M.D.] and she played a psychiatrist [on Cheers]. But the three of us were all trying to buzz at the same time, fighting to get in on the same answer. Those buzzers are tough.

ON HIS MISTAKES I can’t tell you if I won or lost—that’s top secret—but I found my problem was timidity. I didn’t want to miss and be wrong. I kicked myself for not taking more risks. I had people who were sitting in the audience say to me, “I can’t believe you didn’t know so-and-so,” and I knew it, but Neil got in ahead of me.

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