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Was a cast member of: Friends
Now headlining: Go On, premiered Aug. 8
Perry's making some new pals – sans Central Perk – on this NBC comedy, which tells the story of sports radio host and recent widower Ryan King. "It's fine that it follows me," he told the Los Angeles Times of his decade-spanning run on iconic sitcom Friends. "I get it. But I can do other things."
2 of 12
Was a cast member of: Felicity
Now headlining: Last Resort, premiered Sept. 27
Speedman graduates from his dorm days to take on the real world as so-called renegade submarine commander Sam Kendal, who tries to clear his name in this action-packed ABC saga. But Speedman's a proud alum: "When people do stop me, it's about Felicity 99 percent of the time," he told ABC News. "And that's fine with me. That show is close to my heart in a lot of ways."
3 of 12
Was a cast member of: The Facts of Life
Now headlining: Survivor: Philippines, premiered Sept. 19
What would Blair Warner think? The '80s sitcom star kisses her Eastland uniform – and that brilliant do! – goodbye to learn the facts of the Tandang tribe. Roughing it on the CBS reality competition isn't all fun and games, though. "I don't feel like I'm fitting in," a teary-eyed Whelchel said on a recent episode. "I'm already on the outside and don't have somebody I can trust or talk to."
4 of 12
Was a cast member of: Heroes
Now headlining: Nashville, premiering Oct. 10
The blonde beauty has ditched her cheerleading uniform (and sci-fi posse) to embrace a different kind of superpower: her voice. As Connie Britton's younger rival in the ABC musical drama, she'll head to Music City to play Juliette Barnes, whom she describes as "very diva-ish and bratty and snotty sometimes."
5 of 12
Was a cast member of: Desperate Housewives
Now headlining: 666 Park Avenue, premiered Sept. 30
From Wisteria Lane to Manhattan's most enviable address! The former Fairview housewife returns as a domestic diva in ABC's spooky drama. This time, she's Olivia Duran, whose husband (Lost's Terry O'Quinn) owns The Drake, a haunted – yet upscale – apartment building. "It's lush. It's delicious. It's elite," she told ABC News of the dramatized glimpse of the Upper East Side. "It's a world that a lot of people would want to live in and visit and may not be able to escape."
6 of 12
Was a cast member of: Weeds
Now headlining: Animal Practice, premiered Sept. 26
There's nothing illegal going on here for Kirk, whose turn as NBC's animal-loving veterinarian Dr. George Coleman is quite a departure from his comedic tenure on Showtime's marijuana-fueled comedy. In his new gig, Kirk shares the spotlight with The Hangover's Crystal the monkey, who rakes in $12,000 an episode.
7 of 12
Was a cast member of: Ally McBeal
Now headlining: Elementary, premiered Sept. 27
Liu leaves the courtroom behind and breaks the mold as a female Watson in CBS's modern spin on Sherlock Holmes, in which the storied detective (Jonny Lee Miller), fresh out of rehab, takes on New York City. "I think the gender change creates a dynamic and chemistry that you don’t see in the films and the BBC series," she said of filling the traditionally male sidekick's shoes. "I'm not saying it's romantic, but it's a little bit of a tingle."
8 of 12
Was a cast member of: Ugly Betty
Now headlining: Partners, premiered Sept. 24
Talk about a promotion! The one-time Mode magazine fashion assistant is moving on up in CBS's bromantic comedy, in which he and David Krumholtz play partners at an architectural firm. From the minds of Will & Grace's Max Mutchnick and David Kohan, Urie steps out as Louis, whose outside-the-office life is characterized by his relationship with his boyfriend (Brandon Routh), a vegan nurse.
9 of 12
Was a cast member of: The Office
Now headlining: The Mindy Project, premiered Sept. 25
"Every day I wake up, and I'm like, 'I'm the star of my own show, and it has my name on it," Kaling said of her FOX sitcom at a Television Critics Association's discussion this summer. "I'm going to turn into a monster. I can't handle it." Clocking out at the Dunder Mifflin Paper Company (which will close for good after the show's upcoming ninth season), the funny lady will play doctor as a successful gynecologist who is less accomplished in her love life.
10 of 12
Was a cast member of: Law & Order
Now headlining: Guys with Kids, premiered Sept. 26
Anderson's left his job as one of New York City's leading detectives to stay at home with his four kids. He'll report for diaper duty as Gary, who is part-doting dad, part-total dude, in this Jimmy Fallon-produced NBC newcomer.
11 of 12
Was a cast member of: Smallville
Now headlining: Beauty and the Beast, premiered Oct. 11
There's another (albeit hairier) superhuman after Kreuk's heart in this CW reboot of the 1980s series of the same name. Getting serious as homicide detective Catherine "Cat" Chandler, she falls for the ultimate bad boy, who just so happens to morph into a formidable beast when he's angry.
12 of 12
Was a cast member of: Real Housewives of Atlanta
Now headlining: The New Normal, premiered Sept. 11
It's a new reality for the lovably feisty Georgia Peach, who slips out of the Housewife franchise to play Rocky, the not-so-subservient assistant to a soon-to-be father. "I always say, being on a reality show is a blessing and a curse," she told the Wall Street Journal of her segue to scripted television on the Ryan Murphy-produced NBC sitcom. "You get these great opportunities, but people see me as NeNe." Not for long!
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