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From his multiple tattoos to his unpredictable choice of roles, Johnny Depp, 42, coolly strolls to the beat of his own drummer – with a mysterious allure. "He manages to morph into the characters he plays," says his Pirates of the Caribbean costar Orlando Bloom. But no matter his role – be it a rotting-toothed pirate or a man in drag (Before Night Falls) – Depp's chiseled features just can't be masked.
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Nine years after surviving cancer, Armstrong, 34, won his seventh consecutive Tour de France – and an eighth victory could be on the way this summer. "I learn so much from Lance's determination to live life every minute to the fullest," Sheryl Crow has said of her fiancé, whose cancer charity work has helped sell more than 50 million LIVESTRONG bracelets. "Besides, he's hot."
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THE GOOD BROTHER
When Gyllenhaal's older sister Maggie introduced him to Kirsten Dunst in 2002, he trusted her instincts. No surprise there. "He's one of my best friends," says Maggie, three years his senior. And the sibs, who share a passion for acting and politics, also share good genes: The 6 ft.-tall Jarhead star, 24, is a heartthrob. "He's gorgeous, and he's got those big dreamy eyes," says his Moonlight Mile costar Susan Sarandon.
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THE COOL STEPDAD
Long before Kutcher, 27, tied the knot with Demi Moore, he was already a trusted confidante to her daughters Rumer, 17, Scout, 14, and Tallulah, 11, who call him "MOD," or "My Other Dad." "He has taken the kids as his own," says pal Greg Link. "We talk about everything," Kutcher once told Oprah Winfrey. "Between me and Bruce (Willis), I don't know that a guy's ever going to (want to) come in."
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THE FAITHFUL MATE
In his nine-year marriage to Melanie Griffith, Banderas, 45, has stuck with her through the tough times, including her 2000 addiction to painkillers. The couple are so close that when he was filming The Legend of Zorro in Mexico, Griffith got a job as a horse wrangler to be near him. She's "generous, a great mother and a great lover," says Banderas of his wife.
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THE TRIPLE THREAT
He sings, he dances, he acts: What's left for Usher to do? Ask the multitalented performer, 27, and he'll say the sky's the limit. "I've got to become the richest man alive," he says. "I want it all – a little bit of Will Smith, Puffy and Michael (Jackson)." With a leading-man role in the upcoming comedy In the Mix, who knows what the buff star will add to his resume next. "I've got a lot of plans," he says.
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THE AVERAGE JOE
Forget first-class: McConaughey, 35, prefers an Airstream trailer to a flashy limo any day. He's a football-loving, barbeque-cooking ("Ribeyes on the grill – charcoal, not gas," he says) regular guy – who happens to be a movie star. And his sweetie, Penelope Cruz, has no trouble seeing what's so appealing about her man – besides his six-pack abs and killer grin, that is. He has "great charm," she says.
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He sells out stadiums – but the international activist has an even more exclusive audience: heads of state. The U2 frontman, 45, recently sat down for lunch with President Bush and has brought together world leaders including Tony Blair (left) and Germany's Gerhard Schroeder in his quest to lower Third World debt. "I am blown away by this man," Oprah Winfrey once said about the singer. "He's kind of my religion," says Crossing Jordan star Jill Hennessy.
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He's had his share of Hollywood girlfriends, but Damon didn't find his soul mate on a movie set – they met in a bar. And since meeting Argentina-born bartender Luciana Barroso in Miami Beach in 2003, Damon, 35, has treated her like a princess – complete with jaunts to the Bahamas and yachting trips in Italy. Even before getting engaged in September, it was clear that he was "very serious about her," says pal Jamal Prince. And he's taken Barroso's daughter Alexia, 7, under his wing, too.
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THE STYLE SETTER
Beckham, 30, is fearless on the soccer field – and equally daring with his fashions. "David Beckham's got a lot of style. He's a handsome guy and can throw together a good ensemble," says Seal. "And he's always doing something just for kicks, like wearing nail polish." It's no wonder the fit sports star inspires imitation – and has a flock of admirers. "I'm a big David Beckham fan," gushes Hilary Duff.
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THE PROUD PAPA
"Thank God I have a man with a lot of patience who helps me," says Heidi Klum of husband Seal, 42. "The family is our life." The British singer – now dad to son Henry, who was born on Sept. 12 – sets a standard: Even though he's not the biological father of Klum's 1-year-old daughter, Leni (left), he's always considered her his child. "I've dreamt my whole life of having what I have now," he told PEOPLE last year. "I feel complete."
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Not content to rest on his movie-star laurels, McGregor, 34, got his motor running and headed out on the highway for a monster road trip last year. The Stay star completed a 20,000 mile, 3-1/2-month motorcycle tour through 13 countries with pal Charley Boorman. "There were no roads there, just gravel," the Scottish actor says of riding through Mongolia. "But we ploughed on, and I'm glad we did." So are we.