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BRAD PITT, 41
With age, the boyishly handsome blond – twice named PEOPLE's Sexiest Man, in 1995 and 2000 – just keeps getting hotter. Brad Pitt has handled his spilt from wife Jennifer Aniston with grace, is starring in the highly anticipated Mr. and Mrs. Smith with Angelina Jolie and still has time for charity: He recently helped organize a series of public service announcements for The One Campaign, targeting AIDS and poverty.
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ORLANDO BLOOM, 28
From arrow-slinging elf to playful pirate and Hollywood heartthrob, British actor Orlando Bloom embodies debonair charm, onscreen and off. "People are drawn to him, and the adventurous side of him comes through," says actress Diane Kruger (who played Helen to his Paris, in last year's epic Troy). "He's full of life."
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With his socially conscious lyrics, the Colombian singer Juanes is Latin America's answer to Bruce Springsteen and Bono. But he's not just a rocker: Juanes is father to 18-month-old daughter Luna, a job that he says has expanded his musical taste: "I sing Barney songs to her," he tells PEOPLE. "My daughter changed my whole life."
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MATTHEW MCCONAUGHEY, 35
"Matthew looks gorgeous naked," ex Sandra Bullock has said of McConaughey. "He should be naked as much as possible." The actor, who once was caught playing the bongos in the buff and is dating Spanish siren Penelope Cruz, dances to his own beat and looks good doing it. His latest adventure: touring the States in an Airstream trailer to promote his film Sahara.
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JAMIE FOXX, 37
The Ray star's Oscar tribute to his grandmother Estelle brought tears to the audience as the former stand-up comedian accepted his Best Actor honor. But his biggest cheerleader of the night had to be daughter Corinne, who watched her dad from the seats. "I think she's made him grow up a little bit," says former costar Garcelle Beauvais-Nilon of the 10-year-old.
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CLIVE OWEN, 40
The dashing Sin City star's intensity first grabbed moviegoers in 1998's Croupier, but it was Clive Owen's performance in last year's steamy relationship drama Closer that earned him an Oscar nod. But don't think it's all gone to the British actor's head: When his Beyond Borders costar Angelina Jolie told him he looked sexy, she says, he "fell over laughing."
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JOHNNY DEPP, 41
Behind the offbeat persona and flair for whimsy (he'll play Willy Wonka in the upcoming Tim Burton remake) is Johnny Depp's most attractive quality: his commitment to family. "One of the most beautiful things in the world is seeing a mommy with her kids," he told Oprah Winfrey of partner Vanessa Paradis and their children, Lily-Rose, 5 and Jack, 3.
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DAVID BECKHAM, 29
The British soccer star, who plays for Spain's Real Madrid, is a fashion icon – even to other celebs. "I like his crazy bohemian outfits. I think he's really cool," says actress Hilary Duff. His original style is even reflected in the names of his three kids with wife Victoria, the former Posh Spice: newborn Cruz; Romeo, 2; and Brooklyn, 6.
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He's got a shelf full of music's top awards (we've lost count), but it's Usher's dapper style and ripped physique that make him a sex symbol. Says the RampB hit maker, who exercises an hour a day and indulges in manicures and facials: "My fashion sense is part of who I am as an entertainer. It is part of my passion."
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JUDE LAW, 32
"He has amazing eyes, plus he's gorgeous ... everything I could ask for," says Lindsay Lohan of PEOPLE's latest Sexiest Man Alive. And while her sentiments echo those of women across the globe, only one owns his heart. Last Christmas Day the British scene stealer asked 23-year-old girlfriend and Alfie costar Sienna Miller to be his wife, making the actress (in her words) the "happiest girl alive."