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A STARLET IS BORN
Aniston had a handful of false starts in Hollywood before snagging her signature role as Rachel in Friends. She starred in Ferris Bueller, a television adaptation of the full-length film and Molloy in the early 1990s, both of which were cancelled. Somewhat more memorably, she also had a role in 1993's kitschy horror film Leprechaun.
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THE ONE WHERE SHE'S IN FRIENDS
Rachel Green would become Aniston's defining role, of course – the show ran for 10 seasons and attracted nearly 53 million viewers per episode at one point.
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JUST THE RIGHT AMOUNT OF FLAIR
Aniston took four years off from film (perhaps scarred by Leprechaun) and would return slowly, branching out with supporting roles, such as 1996's She's the One and 1997's Office Space.
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Through the early 2000s, Aniston would become a reliable anchor for mainstream comedy (and romantic-comedy) feature-length fare, starring in 2003's Bruce Almighty (her highest-grossing role), 2004's Along Came Polly (left) and The Break-Up. She closed out the decade with two hits: 2008's Marley and Me and 2009's He's Just Not That Into You.
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RETURN TO THE SMALL SCREEN
Aniston picked up an Emmy nomination for outstanding guest actress in a comedy series for her spot on 30 Rock (left) in 2009. She also returned to the small screen opposite Courteney Cox for a guest stint on the latter's Cougar Town in 2009.
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PLAYING AGAINST TYPE
Aniston's role as a sex-crazed dentist in 2013's Horrible Bosses was heralded as a refreshingly against-type decision for her. She doubled down on the offbeat comedy route, costarring with Paul Rudd in the David Wain-directed Wanderlust in 2012, We're the Millers with Jason Sudeikis in 2013, and the Elmore Leonard adaptation Life of Crime in 2014.
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FRIEND TO COMMERCE
Aniston's various business ventures include partnerships with L'Oreal, Elizabeth Arden, Smart Water, Aveeno Skincare, haircare brand Living Proof and Emirates Airline. But not all the money earned stays with her: Anison is involved with a number of charities and donated $500,000 to various relief efforts to help the 2010 Haitian earthquake victims.
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In 2014, Aniston received nominations from the Screen Actors Guild Awards and Golden Globe Awards for her role in Cake, playing a woman traumatized by chronic pain syndrome and the suicide of a woman in her support group.