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Nia Drags Duchovny into Movie Comedy

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“My Big Fat Greek Wedding” writer and star Nia Vardalos has a new leading man — though she will be playing one herself.

According to the Hollywood Reporter, former “X-Files” star David Duchovny, 42, will join Vardalos, 40, and “The Hours” supporting actress Toni Collette, 30, in “Connie and Carla,” from a script by Vardalos, who also is executive producer.

The music-driven project, due to begin filming early next month under the direction of Michael Lembeck (“The Santa Clause 2”), is described as a female-buddy-movie cross between “Some Like It Hot” and “Tootsie.”

According to the trade paper, Vardalos and Collette will play blue-collar dinner-theater singers forced to hide out in drag. Duchovny is set to play the brother of a drag queen who, in searching for his sibling, falls for Vardalos’s character.

In other movie news, Michelle Pfeiffer, 44, is set to star in her first movie comedy in seven years, since the under-appreciated “One Fine Day” with George Clooney (not counting her 1999 turn as Titania in “A Midsummer Night’s Dream”).

The new flick is “She’s Gone,” from a script by “The Hurricane” screenwriter Armyan Bernstein. The Hollywood Reporter describes it as a sophisticated comedy about a husband who hires a man to woo away his wife, only to discover that the husband would still like to stay with her.

Pfeiffer’s costar, director and start date have yet to be announced.