Holmes, 33, drew applause on several occasions – notably, when a telephone she was using in one scene broke, and she deftly fixed it without skipping a beat, even punctuating her dialogue by slapping the broken piece back into place.
She also earned cheers for a defiant speech about Wall Street greed – a recurring theme of the play, in which Holmes plays a Cincinnati woman whose brother returns home with a load of new money and a missing wife.
After the final curtain, Holmes was applauded during her solo bow, though the standing ovations started only when the full cast took their final bow together.
Holmes – who made her Broadway debut in 2008 in a revival of Arthur Miller’s All My Sons – left the Music Box Theatre, just off Times Square, looking sleek in black pants, a black blazer, a cream top, hair pulled back into a bun, and sunglasses.
Asked what it was like to work with Holmes, one of her costars, Josh Hamilton, remarked: “Are you kidding me? She’s a sweetheart.”
Dead Accounts, written by Theresa Rebeck and also starring Judy Greer, Jayne Houdyshell and two-time Tony Award winner Norbert Leo Butz, officially opens Nov. 29.
• Reporting by SHAKTHI JOTHIANANDAN