1 of 7
JOHN & KATY: 6 MONTHS
The couple proved they were in perfect harmony when they cowrote and recorded a sugar-sweet song together, "Who You Love," for Mayer's August album. But there might not be an encore any time soon: After dating on and off since summer 2012, Perry and her duet partner called it quits in February, six months after their ballad debuted.
2 of 7
KHLOé & LAMAR: 1 YEAR, 7 MONTHS
After Kardashian and Odom tied the knot in 2009, fans kept up with their whirlwind romance on the couple's own separate reality show, Khloé amp Lamar. But escalating off-camera drama – including the basketball pro's substance abuse issues – led Kardashian to file for divorce in December, just more than a year and a half after their show ended in May 2012.
3 of 7
ZAC & VANESSA: 2 YEARS, 2 MONTHS
It was young love for Efron and Hudgens, who met while filming 2006's made-for-TV Disney film, High School Musical. But these high school sweethearts didn't make it much past graduation: After the trilogy's final installment arrived in theaters in October 2008, news of their split broke in December 2010.
4 of 7
ADAM & ANNE: 1 YEAR, 2 MONTHS
"He has a million girls drooling over him," gushed the Russian model – but she's the one Maroon 5 frontman (and Sexiest Man Alive) Levine plucked to star in music videos for two of the band's hits, 2010's "Misery" and 2011's "Never Gonna Leave This Bed," after they linked up at a party. Despite their on-screen chemistry, Vyalitsyna confirmed their split in April 2012, telling PEOPLE, "I wish him all the best."
5 of 7
JENNIFER & MARC: 4 YEARS, 10 MONTHS
It was the ultimate duet when Lopez and husband Anthony took their love to the big screen in 2006's El Cantante, a biopic about salsa singer Héctor Lavoe. But nearly five years later – with several more collaborations, including twins Emme and Max, to their names – they split in July 2011 following seven years of marriage.
6 of 7
7 of 7
HEIDI & SEAL: 1 YEAR, 4 MONTHS
Seal didn't have to look far to find the muse for his music video for "Secret," the first single off his 2010 album, Commitment. But nearly a year and a half after the singer stripped down on camera with wife Klum, the couple announced their separation in January 2012 after almost seven years of marriage.