1 of 24
JENNIFER & MARC
In 2011, Lopez and Anthony revealed they were ending their 8-year marriage in a statement to PEOPLE. The star couple share custody of their two children, 7-year-old twins Emme and Maximilian. "I felt like my whole life had fallen apart," Lopez said of the breakup. But the singer assures that there's no bad blood: "We love our kids, and we have love for each other. We always will."
2 of 24
JESSICA & SAM
It was an affair to remember for two-time Oscar winner (and recent Golden Globe nominee) Jessica Lange and her longtime partner, actor-playwright Sam Shepard, who met while co-starring in the 1982 biopic Frances. While their relationship began with an unwelcome spotlight (Shepard left his wife to be with Lange), the couple maintained a life largely out of public view. But after 27 years together, it was revealed the couple ended their relationship almost two years ago. The pair, who have two children together, Hannah and Samuel, "are pursuing independent lives," a source tells PEOPLE.
3 of 24
CHAZ & JENNIFER
Their life together was filmed for OWN's documentary series Becoming Chaz, as Chaz Bono transitioned female to male. With girlfriend Jennifer Elia by his side, the cameras continued rolling for the follow-up special Being Chaz, which captured the couple's engagement after six years together. But on Dec. 19, the pair ended their engagement. "Thanks for your concern about our separation," Bono, 42, Tweeted. "I'm doing fine, and we remain on good terms with nothing but respect and affection 4 each other."
4 of 24
ASHTON & DEMI
Following reports of Ashton Kutcher's alleged infidelity, he and wife of six years Demi Moore went camping with their Kabbalah instructor in what was seen as a retreat to mend the relationship. It didn't work: A month later, Moore announced their split, saying, "As a woman, a mother and a wife there are certain values and vows that I hold sacred, and it is in this spirit that I have chosen to move forward with my life." In reply, Kutcher Tweeted, "I will forever cherish the time I spent with Demi."
5 of 24
ARNOLD & MARIA
After 25 years as husband and wife, Schwarzenegger and Shriver called it quits in 2011, following Schwarzenegger's affair with his former housekeeper, which resulted in a son.
6 of 24
OLIVIA & TAO
Olivia Wilde's fairy-tale marriage to Italian prince Tao Ruspoli ended on Sept. 29, when the Tron actress's divorce was finalized. "The trauma of the whole thing has been humbling," she told Marie Claire. Since then, the sought-after actress has found good company in Hollywood's hottest bachelors, among them Jake Gyllenhaal and Justin Timberlake.
7 of 24
8 of 24
JAMES & LISA
After 11 years of marriage, James Marsden's wife Lisa Linde filed divorce papers in September. A day after the news broke, the friendly exes appeared happy and relaxed in L.A. with their son Jack, 10. "This was a mutual decision," Marsden's rep told PEOPLE, adding that the couple still plans to raise their two children "together and remain great friends."
9 of 24
FRED & ABBY
Proving that the couple that plays together doesn't always stay together, Saturday Night Live costars Fred Armisen and Abby Elliott ended their year-long relationship shortly before the show's fall return. "He was away all summer filming in Portland, she was on location somewhere else," a source told PEOPLE of the comic duo's decision to call it quits.
10 of 24
JESSE & KAT
After months of breakups and makeups, Kat Von D revealed the real reason behind her final split in September with Jesse James. "Today I encountered the 19th girl to add to the list of people Jesse cheated on me with during the last year," Von D wrote in a blog post on her Facebook page, going so far as to acknowledge that she deserves "a big fat 'I told you so.'"
11 of 24
HUGH & CRYSTAL
Five days before her June nuptials to Hugh Hefner, Playmate Crystal Harris had a dramatic change of heart. "It was all just happening too fast for me," the 25-year-old runaway bride told told Ryan Seacrest of why she called off her wedding. But that didn't stop Harris from taking some parting shots at her ex, later telling Howard Stern that sexy with the 85-year-old Playboy founder lasted "like two seconds."
12 of 24
CAMERON & A-ROD
They shared popcorn, house-hunting expeditions and even grueling workouts together, but Cameron Diaz and Yankee slugger Alex Rodriguez's 16-month romance wasn't meant to hit it out of the ballpark. "I have a lot of love for Cameron," A-Rod in September following their split. "We'll always be friends."
13 of 24
LEA & THEO
"I am very happy, I'll say that," Lea Michele admitted in May 2010, shortly after she was spotted kissing fellow Broadway star Theo Stockman at a New York gala. But a mutual love of musical theater wasn't enough to keep the Glee star and the American Idiot actor in sync, and by September 2011, the actress's rep confirmed the couple's split.
14 of 24
MINKA & DEREK
Minka Kelly didn't know anything about baseball before hitting it off with Yankee star Derek Jeter, but she quickly developed a love for the game during their three-year romance. The Charlie's Angel star was even on hand to watch Jeter become the first Yankee player to reach 3,000 career hits in July. But a month later the actress's rep confirmed the relationship had run its course.
15 of 24
MELISSA & BRUCE
The second time seemed to be the charm for Melissa Gilbert and Bruce Boxleitner. Both divorced when they got together in 1992, their courtship led to a 16-year marriage and one son, Michael, 16. But by August 2011, the longtime couple (who also have three adult sons from their previous marriages) decided to call it quits, citing irreconcilable differences.
16 of 24
ALEXANDER & KATE
After meeting on the Louisiana set of 2011 thriller Straw Dogs two years earlier, Alexander Skarsgard and Kate Bosworth looked like a perfect match, cozying up at Coachella and even visiting the True Blood actor's native Sweden together. "He's a wonderful, wonderful man. I adore him," Bosworth told PEOPLE. But by August, reports of a split were confirmed when Bosworth stepped out with a new guy, director Michael Polish.
17 of 24
ASHLEE & PETE
"They're on very friendly terms and speaking – it's fine," a source told PEOPLE of Ashlee Simpson and Pete Wentz's February split. It seems after two-and-a-half years of marriage and the arrival of a son, Bronx, the couple had simply "grown apart." And though a reconciliation looked to be in the works, Simpson and Wentz have both moved on to new romances.
18 of 24
19 of 24
RYAN & AMANDA
It was a Halloween to remember for Amanda Seyfried and Ryan Phillippe, who met at Kate Hudson's annual bash in 2010. "They're really into each other," a source told PEOPLE, after regular sightings of the pair together in L.A. confirmed their blossoming romance. But when Phillippe's former flame, Alexis Knapp, gave birth to the actor's third child in July, Seyfried moved on with New York real-estate exec Andrew Joblon.
20 of 24
BRADLEY & RENéE
"Empathy, humor, wit, self reliance and honesty," are just a few of the traits Renée Zellweger looks for in a man – and she seemed to have found them all in PEOPLE's Sexiest Man Alive Bradley Cooper. But after two low-key years of quietly dating, the Case 39 costar quietly went their separate ways in March.
21 of 24
JOE & ASHLEY
Weeks before their breakup, Ashley Greene couldn't keep her hands off Joe Jonas, who surprised his girlfriend with a Chanel charm bracelet at her 24th birthday bash in Las Vegas on Feb. 19. A month later, the couple signaled the end of their romance when they were spotted – separately – at various L.A. clubs.
22 of 24
DIANNA & ALEX
After meeting on the set of I Am Number Four in summer 2010, British actor Alex Pettyfer quickly impressed Dianna Agron's Glee castmates during an August set visit. "He seems like a really nice guy," Agron's costar Jayma Mays told PEOPLE. By February 2011, engagement rumors swirled around the couple when Agron was spotted wearing a diamond band, but just days later the pair had mysteriously decided to call it quits.
23 of 24
KEIRA & RUPERT
Matching chiseled cheekbones and British accents weren't enough to keep long-term lovers Keira Knightley and Rupert Friend together. Distance and career "were both considerations," a source told PEOPLE in January, after the Atonement actress quietly broke up with her boyfriend of five years. Knightley has since moved on with new beau, British musician James Righton.
24 of 24
GEORGE & ELISABETTA
The Italian actress enjoyed life in the limelight with the two-time Sexiest Man Alive, taking strolls down the Academy Awards red carpet and jetting to Hawaii. "I love it," Canalis told PEOPLE of her romance with the Oscar winner. But two years after stepping out as a couple at the Venice Film Festival, George Clooney and Elisabetta Canalis announced the end of their romance on June 22. By August, the actor had rebounded with a new ladylove, former WWE star Stacy Keibler.
How Stars Dressed Up for Halloween Before They Were Famous
The Pop Culture-Inspired Costumes You Should Definitely Skip This Halloween
Watch Julianne Moore, Emma Stone and Melissa McCarthy Urge You to Demand Stricter Gun Laws