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The seven-months-pregnant star was blind-sided when longtime boyfriend Billy Crudup left her for Claire Danes. But the brunette beauty came out on top, welcoming son William Atticus on Jan. 7, 2004 – and winning a Golden Globe 18 days later (for Angels in America). But the best moment: thanking her newborn "for my boobs looking so good in this dress."
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When her nearly 5-year marriage to Brad Pitt ended – and attention on his new love Angelina Jolie reached a fever pitch in 2005 – Aniston threw herself into work and kept mum. That is, until a sexy, topless Vanity Fair cover hit stands six months later. In it, she refrained from bashing on her ex, simply saying, "What doesn't kill you makes you stronger."
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First the singer and Lance Armstrong split in February 2006, just months before their wedding. Then came another blow: breast cancer. Weeks later, she was in surgery. The experience "really made me consider how I wanted the rest of my life to look," Crow said, leading to her adoption of son Wyatt in April 2007. "He's enhanced my life one hundred-fold."
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She left the abusive Ike Turner in 1976 with only the shirt on her back, and spent years playing lounge gigs to pay off debts. So, at 45, when Turner triumphed in '85 with record of the year and two other Grammys, it was a comeback of sweet proportions. "I can get emotional when I talk about it," the "What's Love Got to Do With It" singer said in 2005 of her career, before retiring. "It's almost like the war is over. It's all finished. You've arrived. You got there."
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In 2008, the country singer had a shock: Her husband of 14 years, songwriter Robert "Mutt" Lange, had had an affair with longtime friend Marie-Ann Thiébaud. But she turned the tables, going public with her former pal's ex, Frédéric (pictured), and channeling her pain into a new show for Oprah Winfrey's cable network, Why Not? With Shania Twain, where she'll share her "experience of recovery."
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Just months after she became the first African American Best Actress winner in '02, cheating husband Eric Benét checked into rehab for sex addiction; two years later they would divorce. "I will never, never get married again," she told InStyle. That vow didn't keep Berry from her dream: At 41, she gave birth to daughter Nahla, with partner Gabriel Aubry. "I've waited a long time for this moment in my life," she said.
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Success could be the best revenge: After the original Mrs. Donald Trump walked away from her cheating husband with an estimated $20 million in '91, she went on to publish a romance novel and a divorce manual, launch a jewelry line and a perfume, and raise her three children. "I am doing now things I would never have been able to do if I were still with Donald," she told PEOPLE. "Now, I don't account to anybody, and it's fabulous."
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"You have to be true to yourself," Clinton said about facing up to her husband's trysts – including White House intern Monica Lewinsky in 1998. "You have to do what is right for you and that may not be what anybody else believes.” For the New York senator, that was sticking by Bill, and going on to become the country's first legitimate female presidential candidate, before joining President Barack Obama as Secretary of State – with her husband behind her.
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Ten days after winning a career-validating Oscar, her world was rocked by revelations of husband Jesse James's infidelity. But his mistakes couldn't take away all happiness. Two months later she broke her silence with a joyful PEOPLE cover – the news that she was adopting a baby boy on her own and getting a divorce.