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On Monday, Jimmy Kimmel delivered a tearful monologue on his late-night talk show, revealing his son William was born with tetralogy of Fallot with pulmonary atresia, a congenital heart disease.
Kimmel chronicled the time after Billy was born, to three hours later when a nurse noticed something was wrong, to the time the baby boy had surgery.
"He'll have to have another open-heart surgery in three to six months," Kimmel shared, adding that Billy will need a third "hopefully non-invasive procedure" when he's in his early teens.
The new dad of four joked: "Poor kid. Not only did he get a bad heart, he got my face."
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LEO THAMES NEWMAN
Jaime King's 21-month-old son, Leo Thames, faced a major hurdle at 4 months old. In 2016, the Hart of Dixie actress bravely shared her son underwent surgery after being diagnosed with a rare heart defect called transposition of the great arteries.
While the star called the experience "terrifying" and "traumatic" for her family, she did feel the support from close friends — including Leo's godmother, Taylor Swift, who made a tribute gift donation to Cedars-Sinai following Leo's successful procedure.
"I have a voice and I want to use that voice on behalf of my son — and I know that my son would want that," King told PEOPLE on her reasoning behind publicly sharing her son's story. "He's so strong. He's such a fighter. He's unbelievable."
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The eldest Stallone sister, Sophia (pictured right), first underwent a successful heart surgery at just 2 months old, when doctors corrected a congenital malformation of a valve.
This wasn't the last time for Sylvester Stallone's 20-year-old daughter, however. Sophia most recently underwent heart surgery in 2012 – the same year her half-brother, Sage, tragically died from heart complications.
Before the successful operation in 2012, Sophia told Paris Match, "Every day I think of my heart. I eat really healthy, and as I get more tired than normal, I have to be very careful when doing sports."
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At 6 years old, Baylee, now 14 — pictured here with dad Brian Littrell (left) and Backstreet Boys member A.J. McLean — endured a life-threatening illness after experiencing a series of symptoms, which included high fevers, full-body rash, swollen lymph nodes and blisters that coated his throat.
The diagnosis: atypical Kawasaki disease, an inflammation of the blood vessels that in extreme cases can lead to aneurysms and sudden death. Littrell told PEOPLE in 2009: "We didn't know what we were dealing with until we found his coronary artery three times the size it should be."
Immediately following his diagnosis, Baylee began the standard treatment of a 12-hour course of IVIG, a medication designed to reduce arterial inflammation. He has made a full recovery.
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In 2009, Katherine Heigl and husband Josh Kelley adopted 9-month-old daughter, Naleigh, from South Korea.
The couple's eldest daughter, now 8, was born with a congenital heart problem that was fixed via open-heart surgery before she left Korea according to a Harper’s Bazaar story from 2010.
"Her heart is 100 percent fine now," Heigl told the magazine at the time.